Hypogonadism: deficiency of testosterone, growth, and fertility

If the growing child or adult man does not have enough testosterone in the body, it can have far-reaching consequences. The child may have growth retardation, puberty does not last and fertility is at stake. What does hypogonadism mean, what disorders can it cause and what are the consequences?

Influence of the male sex hormone

Testosterone is normally produced by testicles so that fertility is stimulated. A shortage means that the man has less chance of producing offspring. In addition, the strength in the body decreases because muscles are stimulated less. The male characteristics are therefore less emphasized. In addition, the growing child may experience growth retardation and puberty may be delayed or absent altogether. The following main distinction is made.


Primary deficit: testicles

If the balls function optimally, sufficient testosterone is available. If it is insufficiently created in the balls then it has a direct influence on the functioning of the man. Fewer sperm is produced, in addition to which the amount of muscle decreases. Growth spurts stay out, so the child remains relatively small. Because afterward the proportion of estrogen increases, people will soon retain fluids and fats and the person arrives quickly. It can be caused by the position of the balls, disorders of the scrotum and other internal testicular disorders.


Secondary deficiency: pituitary gland

At the bottom of the brain is a small gland, through which many hormone-producing substances are released. The amount of testosterone produced by the testicles is determined by the pituitary gland. If, however, this gland works too slowly due to ailments or diseases, then the male sex hormone is inadequate. In other words, fertility is at stake.


Underlying syndromes of seed balls

The onset of hypogonadism can already be determined at birth, but can also be caused by physical disorders or diseases with aging. For example, it may happen that the balls do not develop or hardly develop, causing various problems. Think further about the following causes related to the balls.


The clinic fever syndrome

Already from the fertilization of the egg cell, all DNA is fixed. The man always has one Y chromosome and at least two (and sometimes several) X chromosomes. In one in five hundred born boys, there is a deviation within the chromosomes. It results in complaints such as difficulty concentrating, difficulty with communication and rapid fatigue. This is largely caused by a defective production of testosterone.



After birth, the testes should descend as standard, so that it ends up in the scrotum. In this condition, the descent is omitted, the balls remain stuck in the abdomen (too small opening in the abdominal wall) or the associated vas deferens or blood vein are deficient. Several problems can cause the balls to not end up in the right place. It is necessary that the balls are surgically applied in the right place.


In addition, it can be inflammation of the balls, such as in an STD, but also chemo or surgical removal can cause a shortage of the male hormone.


Diseases of the pituitary gland

In the case of the pituitary, there are also various reasons why the secondary variant occurs. The pituitary gland does not produce sufficient testosterone stimulating hormones so that the balls secrete little male hormone. Think of the following causes.


Syndrome of Kallman

There is normally a connection between the pituitary gland and hypothalamus so that the pituitary gland knows which hormone-releasing substances must be secreted. If that compound is not present, then a series of necessary hormones are not given to the body. In other words, the child does not get growth spurts, puberty stays out and the person is infertile. This circumstance should be diagnosed early so that the right hormones are administered in a timely manner. This then applies to life.


Dandy-Walker Syndrome

The vermis (middle part of the cerebellum of the brain) has not grown, in addition to which cysts also apply. The brain disorder results in an excessive growth of the head, leaving the physical growth behind. The production of the male hormone largely remains, causing growth and fertility problems. One often has to vomit, in addition to which there is increasing distraction and irritation.


The pituitary gland may have good and malignant tumors. In addition, there may be iron overload due to, for example, regulated blood transfusions. Medications and the age of the person can also influence the release of hormone-producing substances.


Consequences and medication in hypogonadism

In different stages of life, a shortage of testosterone has various consequences. Already during the growth in the womb, it can lead to the inadequate growth of the genitals and the balls. Determining the gender can then be difficult. Due to a limited amount of testosterone, the child will grow less quickly and puberty will come at a later date. It also leads to less or no hair in characteristic areas such as the pubic area and armpits. Sexuality, erectile functioning, fertility, and voice are affected. In addition, gynecomastia can occur later in life(male breasts), osteoporosis, overweight and mood swings apply. If it is recognized in time, testosterone can be administered as a medication, so that all stages of life are passed through normally.


If your child has growth retardation, it can be caused by hypogonadism. In order to achieve growth spurts, puberty, and fertility, the child should be helped at an early age. Check with the treating pediatrician.